スタッフ紹介

臨床研究イノベーションセンター 特任准教授

山崎 大Hajime Yamazaki

【略歴】

北海道旭川市出身。2008年に宮崎大学を卒業。札幌の手稲渓仁会病院で8年間、消化器内科医として研鑽を積む。2016年に京都大学大学院に入学し、福原俊一教授のもとで臨床疫学を学ぶ。2019年に医学博士号取得し、同年より京都大学 地域医療システム学講座 特定講師。2023年より福島県立医科大学 特任准教授と熊本大学 客員准教授を兼任。

脂肪肝や脂肪膵などの脂肪分布に関する臨床疫学研究と、炎症性腸疾患のレジストリー研究、患者報告型アウトカムやPatient and Public Involvement (PPI)に関する研究を行うとともに、臨床研究教育に携わる。

消化器・内視鏡・肝臓・総合内科専門医。日本炎症性腸疾患学会代議員。社会医学系専門医。臨床疫学上席専門家。 

【主な臨床研究】 

  1. Yamazaki H, Streicher SA, Wu L, Fukuhara S, Wagner R, Heni M, Grossman SR, Lenz HJ, Setiawan VW, Marchand LL, Huang BZ. Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study. medRxiv [Preprint]. 2023.04.20.23288770. doi: 10.1101/2023.04.20.23288770.
  2. Matsuoka K, Yamazaki H, Nagahori M, Kobayashi T, Omori T, Mikami Y, Fujii T, Shinzaki S, Saruta M, Matsuura M, Yamamoto T, Motoya S, Hibi T, Watanabe M, Fernandez J, Fukuhara S, Hisamatsu T. Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study. Journal of Gastroenterology. 2023;58(8):751-765.
  3. Yamamoto R, Yamazaki H, Kobara S, Iizuka H, Hijikata Y, DrPH1, Miyashita J, Kataoka Y, Yajima, N, Miyata T, Hamaguchi S, Wakita T, Yamamoto Y, Fukuhara S. Development and initial psychometric validation of the COVID-19 Pandemic Burden Index for healthcare workers. Journal of General Internal Medicine. 2023; 38(5):1239-1247.
  4. Yamazaki H, Tauchi S, Machann J, Haueise T, Yamamoto Y, Dohke M, Hanawa N, Kodama Y, Katanuma A, Stefan N, Fritsche A, Birkenfeld AL, Wagner R, Heni M. Fat-distribution patterns and future type-2 diabetes. Diabetes. 2022;71(9):1937-1945.
  5. Wagner R, Eckstein S, Yamazaki H, Gerst F, Machann J, Jaghutriz B, Schürmann A, Solimena M, Singer S, Königsrainer A, Birkenfeld A, Häring HU, Fritsche A, Ullrich S, Heni M. Metabolic implications of pancreatic fat accumulation. Nature Reviews Endocrinology. 2022;18(1):43-54.
  6. Yamazaki H, Wang J, Tauchi S, Dohke M, Hanawa N, Katanuma A, Saisho Y, Kamitani T, Fukuhara S, Yamamoto Y. Inverse Association Between Fatty Liver at Baseline Ultrasonography and Remission of Type-2 Diabetes Over a 2-year Follow-up Period. Clinical Gastroenterology and Hepatology. 2021;19(3):556-564.
  7. Yamazaki H, Tauchi S, Wang J, Dohke M, Hanawa N, Kodama Y, Katanuma A, Saisho Y, Kamitani T, Fukuhara S, Yamamoto Y. Longitudinal association of fatty pancreas with the incidence of type-2 diabetes in lean individuals: a 6-year computed tomography-based cohort study. Journal of Gastroenterology. 2020;55(7):712-721.
  8. Yamazaki H, Matsuoka K, Fernandez J, Hibi T, Watanabe M, Hisamatsu T, Fukuhara S. Ulcerative colitis outcomes research in Japan: protocol for an observational prospective cohort study of YOURS (YOu and Ulcerative colitis: Registry and Social network). BMJ open. 2019;9(9):e030134. doi: 10.1136/bmjopen-2019-030134.
  9. Yamazaki H, Tsuboya T, Katanuma A, Kodama Y, Tauchi S, Dohke M, Maguchi H. Lack of independent association between fatty pancreas and incidence of type 2 diabetes: 5-year Japanese cohort study. Diabetes Care. 2016;39(10):1677-83.
  10. Yamazaki H, Tsuboya T, Tsuji K, Dohke M, Maguchi H. Independent association between improvement of nonalcoholic fatty liver disease and reduced incidence of type 2 diabetes. Diabetes Care. 2015;38(9):1673-9.

 

 

 

山崎 大